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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NF1
All Species:
26.67
Human Site:
Y489
Identified Species:
58.67
UniProt:
P21359
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21359
NP_000258.1
2839
319372
Y489
T
D
L
E
T
R
S
Y
K
Y
L
L
L
S
M
Chimpanzee
Pan troglodytes
XP_511395
2839
319368
Y489
T
D
L
E
T
R
S
Y
K
Y
L
L
L
S
M
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_537738
2824
317549
Y472
T
D
L
E
T
R
S
Y
K
Y
L
L
L
S
M
Cat
Felis silvestris
Mouse
Mus musculus
Q04690
2841
319577
Y489
T
D
L
E
T
R
S
Y
K
C
L
L
L
S
M
Rat
Rattus norvegicus
P97526
2820
317065
Y489
T
D
L
E
A
R
S
Y
K
Y
L
L
L
S
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506475
2851
320923
Y500
T
D
L
E
T
R
S
Y
K
Y
L
L
L
S
M
Chicken
Gallus gallus
XP_415914
2833
319514
Y489
T
D
L
E
T
K
S
Y
K
F
L
L
L
S
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_692937
2750
310306
V453
A
E
T
L
G
R
V
V
Q
G
C
S
H
T
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001014668
2764
312956
Q494
D
T
L
N
K
A
T
Q
G
Y
I
A
H
T
P
Honey Bee
Apis mellifera
XP_624747
2748
312616
Q489
L
T
L
K
G
K
E
Q
N
K
Y
R
D
R
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001197154
1913
215693
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
N.A.
98.8
N.A.
98.4
97.8
N.A.
95.3
95.2
N.A.
85.6
N.A.
55.5
56
N.A.
40.3
Protein Similarity:
100
100
N.A.
99.1
N.A.
99.3
98.6
N.A.
97.4
97.8
N.A.
91.3
N.A.
71.2
71.6
N.A.
52.3
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
100
80
N.A.
6.6
N.A.
13.3
6.6
N.A.
0
P-Site Similarity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
100
100
N.A.
26.6
N.A.
33.3
20
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
10
10
0
0
0
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
10
0
0
0
0
% C
% Asp:
10
64
0
0
0
0
0
0
0
0
0
0
10
0
0
% D
% Glu:
0
10
0
64
0
0
10
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
0
0
0
19
0
0
0
10
10
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
19
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% I
% Lys:
0
0
0
10
10
19
0
0
64
10
0
0
0
0
0
% K
% Leu:
10
0
82
10
0
0
0
0
0
0
64
64
64
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
55
% M
% Asn:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
0
0
0
0
19
10
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
64
0
0
0
0
0
10
0
10
0
% R
% Ser:
0
0
0
0
0
0
64
0
0
0
0
10
0
64
0
% S
% Thr:
64
19
10
0
55
0
10
0
0
0
0
0
0
19
10
% T
% Val:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
64
0
55
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _